Sona Nanotech Inc. (CSE: SONA), (OTCQB: SNANF) (the “Firm” or “Sona”) is happy to announce an modern analysis initiative to be undertaken with The Giacomantonio Immuno-Oncology Analysis Group (the “Analysis Group”). This examine goals to guage the efficacy of Sona’s Focused Hyperthermia Remedy (“THT”) know-how in not solely attenuating the event of colorectal, breast, and melanoma tumor fashions in mice but additionally in facilitating systemic immune responses.
The examine posits that the mixed utilization of Sona’s gold nanorods by way of its Focused Hyperthermia Remedy, alongside exact immune modulation, will lead to elevated immune activation and anti-tumor responses throughout the mouse fashions of colorectal most cancers, breast most cancers, and melanoma.
Sona CEO, David Regan, commented, “This modern examine will go considerably past our present plans for Focused Hyperthermia Remedy purposes to discover the doubtless synergistic impact of its use with sure immunotherapy remedies for most cancers. In it, we goal to harness the super potential of immunotherapy, leveraging Sona’s biocompatible gold nanorods as a pivotal, catalytic aspect. This effort marks the start of Sona delivering on the ‘mountain of knowledge’ we dedicated to creating in help of our deliberate regulatory submissions for human scientific trial approvals.”
Dr. Carman Giacomantonio, principal investigator of the Analysis Group, commented, “We’re dedicated to exploring two distinct but interrelated organic processes with the potential to unlock the elusive Holy Grail of intra-tumoral most cancers immunotherapies, often known as the Abscopal Impact. The primary avenue capitalizes on the kinetic excitation of gold nanorods, able to inducing localized tumor destruction. This course of exposes potent tumor neo-antigens, which may then be strategically mobilized to immune-responsive websites. This technique holds the potential of profoundly reshaping and amplifying the efficacy of the immune response in opposition to most cancers. Concurrently, the second dimension of our analysis delves into the profound impression of intralesional immunomodulation within the context of each native and systemic Focused Hyperthermia Remedy. Collectively, these aims, if profitable, could set up a strategic framework to light up the trail in direction of groundbreaking, modern, and potent immunotherapeutic interventions for colorectal most cancers, breast most cancers, and melanoma.“
Sona CSO, Len Pagliaro, PhD, commented, “We’re excited and happy to have the chance to collaborate with The Giacomantonio Immuno-Oncology Analysis Group. The deliberate research will carry the intensive information and expertise of Dr. Giacomantonio to bear in a sublime and complex examine that may enhance our understanding of each the mechanisms and capabilities of THT. The findings of this examine will assist inform and enhance our deliberate first-in-human research as we strategy that necessary milestone.”
To facilitate the examine, the Firm and the Analysis Group have entered right into a Analysis Settlement underneath which experiments will probably be performed. The experiments will discover immune reprogramming by tumor antigen switch in addition to tumor response and immune modulation in subcutaneous tumor fashions following therapy with numerous immunotherapeutic interventions. The Firm will cowl as much as a most of $80,000, which is roughly 40% of the examine’s anticipated price, which is able to embrace in-kind contributions of the Firm and its laboratory. The Analysis Group will present numerous interim outcomes to be supplied to the Firm and could have the best to publish findings from the examine. The examine is to be performed on the Giacomantonio Laboratory at Dalhousie College in Halifax, Nova Scotia. The outcomes of the examine are anticipated to supply information that may type a part of any future regulatory submissions in help of the event of its Focused Hyperthermia Remedy.
Contact:
David Regan, CEO
+1-902-536-1932
david@sonanano.com
About Sona Nanotech Inc.
Sona Nanotech, a nanotechnology life sciences firm, is creating Focused Hyperthermia™, a photothermal most cancers remedy, which makes use of therapeutic warmth to deal with strong most cancers tumors. The warmth is delivered to tumors by infrared mild that’s absorbed by Sona’s gold nanorods within the tumor and re-emitted as warmth. Therapeutic warmth (44°C) stimulates the immune system, shrinks tumors, inactivates most cancers stem cells, and will increase tumor perfusion – thus enabling medicine to succeed in all tumor compartments extra successfully. The dimensions, form, and floor chemistry of the nanorods goal the leaky vasculature of strong tumors, and the selective thermal sensitivity of tumor tissue permits the remedy to ship clear margins. Focused Hyperthermia guarantees to be protected, efficient, minimally invasive, aggressive in price, and a invaluable adjunct to drug remedy and different most cancers remedies. Sona’s preliminary scientific goal is colorectal most cancers.
Sona has developed a number of proprietary strategies for the manufacture of gold nanoparticles which it makes use of for the event of each most cancers therapies and diagnostic testing platforms. Sona Nanotech’s gold nanorod particles are cetyltrimethylammonium (“CTAB”) free, eliminating the toxicity dangers related to the usage of different gold nanorod applied sciences in medical purposes. It’s anticipated that Sona’s gold nanotechnologies could also be tailored to be used in purposes, as a protected and efficient supply system for a number of medical remedies, topic to the approval of varied regulatory boards, together with Well being Canada and the FDA.
CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING INFORMATION: This press launch consists of sure “forward-looking statements” underneath relevant Canadian securities laws, together with statements relating to the anticipated purposes of Focused Hyperthermia Remedy, Sona’s plans to build up information in help of attainable submissions in search of FDA and Well being Canada approvals and clearances for Sona’s merchandise underneath growth and the potential impression of the deliberate examine. Ahead-looking statements are essentially based mostly upon quite a few assumptions or estimates that, whereas thought-about affordable, are topic to recognized and unknown dangers, uncertainties, and different components which can trigger the precise outcomes and future occasions to vary materially from these expressed or implied by such forward-looking statements, together with the chance that Sona could not have the ability to efficiently acquire adequate scientific and different information to submit regulatory submissions, increase adequate further capital or develop the envisioned remedy, and the chance that THT could not show to have the advantages presently anticipated. There might be no assurance that such statements will show to be correct, as precise outcomes and future occasions may differ materially from these anticipated in such statements. Accordingly, readers mustn’t place undue reliance on forward-looking statements. Sona disclaims any intention or obligation to replace or revise any forward-looking statements, whether or not on account of new info, future occasions or in any other case, besides as required by legislation.
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